Endocrine Abstracts

Introduction: Non-Hodgkin lymphoma (NHL) involving the thyroid gland constitutues 2–3% of all NHL cases, 2–8% of all thyroid malignancies. The majority of lymphomas arising in the thyroid gland are MALT lymphomas and diffuse large B cell lymphomas commonly occuring in the setting of thyroiditis. Most cases are seen in adult or elderly females. The thyroid enlargement is often rapid and can lead to symptoms of tracheal or laryngeal compression. Herein, we present a ca...

Introduction: The neurohormones A and B-type natriuretic peptides are markedly increased in patients with heart disease, and are well established as useful diagnostic biomarkers. Obesity is a known risk factor for cardiovascular disease. Cross sectional data suggest however that plasma levels are reduced among obese. Therefore, the aim of the present study was to investigate the impact of weight loss and corresponding changes in body composition on plasma levels of A and B-typ...

The anti-CD20 antibody Rituximab (RTX) induces peripheral B cells depletion. Aim of the present study was to evaluate changes of lymphocytes after RTX therapy, administered at the dosage of 1000 mg twice at 2-week interval, in 10 patients with Graves’ disease, 8 of whom had associated ophthalmopathy (TAO). In all patients, we studied the standard immunophenotypic panel before therapy and monthly for up to 2 years. Total CD20+ (and CD19+) cell depletion was observed after ...

Introduction: Carbohydrate metabolism disorders are common in chronic liver diseases, from glucose intolerance to proven diabetes. The presence of diabetes during chronic liver disease is a factor of poor prognosis. The purpose of our study is to assess the prevalence of diabetes in chronic hepatitis B and C and to determine the risk factors.Patients and methods: This is a retrospective study that collects all cases of chronic hepatitis hospitalized in t...

Introduction: Sheehan’s syndrome presents with hypopituitarism of variable severity after parturition usually preceded by post partum hemorrhage. Recovery of lactotroph function after initial insult has not been reported in the literature.Case report: A 41-year woman delivered her 1st child in 1994 at the age of 25 years, complicated by profuse vaginal bleeding and received two blood transfusions at a city hospital. She had lactation failure ...

Introduction: Primary adrenal lymphoma is extremely rare. It accounts for <1% of extranodal lymphoma. It affects typically old males with bilateral adrenal gland involvement that leads to adrenal hypofunction. Prognosis is very poor due to the lack of optimum chemotherapeutic regimens.Case Report: A 71 yearr old man with prior history of non insulin dependent diabetes, was admitted to the emergency department with symptoms of progressive weakness, fa...

Introduction: Diabetes mellitus is known as a factor of cognitive impairment. The risk of dementia in patients with type 2 diabetes mellitus (T2DM) increases almost twice. The results of epidemiological, visualization and autopsy studies showed the presence of both cerebrovascular and neurodegenerative mechanisms of brain lesions. Cell death of key substrates – neurons and endothelial cells lays in the basis of the formation of cerebral disorders. Granzyme B (GrB) is a s...

Background: Cancer of thyroid gland is rare in childhood, representing 1% of all pediatric malignancies. Primary thyroid lymphoma (PTL) is even rarer accounting for 5% of thyroid malignancies and 2% of extranodal lymphomas. The disease affects mainly adults in thesixth orseventh decade of life, with a female predominance. Most thyroid lymphomas are non-Hodgkin’s lymphomas (nHL) of B-cell origin. The most common type is Diffuse Large B- cell Lymphoma (DLBCL). Patients wit...

Somatic activating mutations in BRAF, encoding B-Raf, have been described in tumours and recently craniopharyngiomas. Germline mutations in BRAF and other components of the RAS/MAPK pathway are found in RASopathies, whose features include endocrine deficiencies but not craniopharyngiomas. We report three BRAF mutations (two of which are novel) in four children with congenital hypopituitarism. To demonstrate the functional role of the three variants w...

Somatic activating mutations in BRAF, encoding B-Raf, have been described in tumours and recently craniopharyngiomas. Germline mutations in BRAF and other components of the RAS/MAPK pathway are found in RASopathies, whose features include endocrine deficiencies but not craniopharyngiomas. We report three BRAF mutations (two of which are novel) in four children with congenital hypopituitarism. To demonstrate the functional role of the three variants w...